Population
Murine model infected with Coxsackievirus type B4 (CBV-4) strains (parent Mil strain and antigenic variants)
Comparison
Infection with antigenic variants of CBV-4… vs Infection with the parent Mil strain of CBV-4
Design
Preclinical
Authors
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Suggests antigenic determinants modulate CVB4 myocarditis in mice; hypothesis-generating and should not change clinical practice.
Antigenic variation in Coxsackievirus B4 alters its myocarditic and cardiotropic properties in a murine model, suggesting a link between viral antigenic determinants and cardiac pathology.
Cao et al. (1984) studied this question.
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