Why the study?
Does oral poliovirus vaccination induce intestinal antibody responses that coincide with the decline of poliovirus excretion in children previously immunized with inactivated poliovirus vaccine?
Population
66 children immunized with 3 doses of enhanced-potency inactivated poliovirus vaccine (E-IPV)
Comparison
1 dose of monovalent oral poliovirus vaccine vs Trypsin-modified E-IPV versus regular E-IPV
Design
Cohort
Follow-up
9 fecal samples collected after OPV vaccination
Authors
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Intestinal IgA responses may coincide with reduced poliovirus excretion after OPV in E-IPV-primed children; leaves open effects on shedding duration or booster needs.
Does oral poliovirus vaccination induce intestinal antibody responses that coincide with the decline of poliovirus excretion in children previously immunized with inactivated poliovirus vaccine?
Intestinal antibody responses, mainly IgA, following OPV vaccination coincide with the cessation of primary poliovirus excretion in children previously immunized with E-IPV.
Valtanen et al. (2000) studied this question.
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