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April 1, 1959The Journal of Experimental MedicineOpen Access

Double Infections of Single Cells With Echo 7 and Coxsackie A9 Viruses

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Population

Monkey kidney cultures in monolayer (rhesus and patas) and newborn mice

Design

Preclinical

Authors

HIH ItohKyushu HospitalJMJoseph L. MelnickStatens Serum Institut

Discussion

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Implication

Supports further study of enteroviral evolution; leaves open clinical relevance in human coinfections.

Structured PICO

P
Population
Monkey kidney cultures in monolayer (rhesus and patas) and newborn mice
I
Intervention
Double infection with high multiplicities of Coxsackie A9 (CA9) and ECHO 7 (E7) viruses
O
Outcome
Characterization of virus particles released by individual cells (phenotypic vs genotypic mixing)surrogate

The study demonstrates that phenotypic, but not genotypic, mixing occurs between Coxsackie A9 and ECHO 7 viruses in doubly infected single cells.

Cite This Study

Itoh et al. (1959) studied this question.

synapsesocial.com/papers/6a87d1a7f455bdf6826c8ccbhttps://doi.org/10.1084/jem.109.4.393
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Morphologic Characteristics of Plaques Produced on Monkey Kidney Monolayer Cultures by Enteric Viruses (Poliomyelitis, Coxsackie, and Echo Groups)1957 · 94 citations
  2. 2Experimental Production of Combination Forms of Virus. IV. Mixed Influenza A-Newcastle Disease Virus Infections1954 · 43 citations
  3. 3Development of Virus-Like Particle Technology from Small Highly Symmetric to Large Complex Virus-Like Particle Structures2013 · 5,966 citations
  4. 4THE EXPERIMENTAL PRODUCTION OF COMBINATION FORMS OF VIRUS1954 · 51 citations
  5. 5THE EXPERIMENTAL PRODUCTION OF COMBINATION FORMS OF VIRUS1953 · 89 citations