February 1, 2001Journal of Cardiovascular Pharmacology

Increase in Myofibrillar Ca2+ Sensitivity Induced by UD-CG 212 Cl, an Active Metabolite of Pimobendan, in Canine Ventricular Myocardium

View Full Paper

Ask AI

Bookmark

Why the study?

Does UD-CG 212 Cl increase myofibrillar Ca2+ sensitivity in canine ventricular myocardium?

Population

Canine ventricular trabeculae loaded with aequorin

Comparison

UD-CG 212 Cl up to 10 M vs Elevation of extracellular calcium ([Ca2+]o)

Design

Preclinical

Authors

RTReiko TakahashiShizuoka General Hospital MEMasao EndohYamagata University

Discussion

Member takes

Implication

Supports pimobendan metabolite mechanism in canine models; hypothesis-generating for human translation, no practice change.

Structured PICO

Does UD-CG 212 Cl increase myofibrillar Ca2+ sensitivity in canine ventricular myocardium?

Population

Canine ventricular trabeculae loaded with aequorin

Intervention

UD-CG 212 Cl (an active metabolite of pimobendan) up to 10(-5) M

Comparator

Elevation of extracellular calcium ([Ca2+]o)

Outcome

Mechanism of positive inotropic effect (force and Ca2+ transients)surrogate

UD-CG 212 Cl, an active metabolite of pimobendan, exerts a positive inotropic effect partly by increasing myofibrillar Ca2+ sensitivity via a cAMP-dependent signal transduction pathway.

Cite This Study

Takahashi et al. (2001) studied this question.

synapsesocial.com/papers/6a87d2fa7d1a7154c501623e https://doi.org/10.1097/00005344-200102000-00008

View Full Paper

Ask AI

Bookmark

Increase in Myofibrillar Ca2+ Sensitivity Induced by UD-CG 212 Cl, an Active Metabolite of Pimobendan, in Canine Ventricular Myocardium

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Increase in Myofibrillar Ca2+ Sensitivity Induced by UD-CG 212 Cl, an Active Metabolite of Pimobendan, in Canine Ventricular Myocardium

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider