January 1, 1996Journal of Hypertension

Vascular and cardiac overexpression of endothelin-1 gene in one-kidney, one clip Goldblatt hypertensive rats but only in the late phase of two-kidney one clip Goldblatt hypertension

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Population

Rat models of Goldblatt renovascular hypertension (one-kidney, one clip and two-kidney, one clip)

Comparison

One-kidney, one clip and two-kidney, one clip… vs Control unilaterally nephrectomized rats

Design

Preclinical

Follow-up

up to 8 weeks

Authors

PSPavol SventekMedical Council of Canada ATA. TurgeonHôpital de l'Enfant-Jésus RARa l Garc a

Discussion

Member takes

Implication

ET-1 timing differs by hypertension model in rats; extends preclinical insights but leaves open human relevance.

Structured PICO

Population

Rat models of Goldblatt renovascular hypertension (one-kidney, one clip and two-kidney, one clip)

Intervention

One-kidney, one clip (1K1C) and two-kidney, one clip (2K1C) Goldblatt hypertension models

Comparator

Control unilaterally nephrectomized rats

Outcome

Endothelin-1 gene expression in blood vessels (aorta, mesenteric arteries) and heart (ventricles, left atria) measured by Northern blot analysissurrogate

Endothelin-1 gene overexpression occurs early in non-renin-dependent, volume-expanded models of hypertension (1K1C) but only late in initially renin-dependent models (2K1C), correlating with the development of vascular hypertrophy.

Cite This Study

Sventek et al. (1996) studied this question.

synapsesocial.com/papers/6a87d6a6028b9097c3e95b60 https://doi.org/10.1097/00004872-199601000-00008

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Vascular and cardiac overexpression of endothelin-1 gene in one-kidney, one clip Goldblatt hypertensive rats but only in the late phase of two-kidney one clip Goldblatt hypertension

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Vascular and cardiac overexpression of endothelin-1 gene in one-kidney, one clip Goldblatt hypertensive rats but only in the late phase of two-kidney one clip Goldblatt hypertension

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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