Population
rat aortic smooth muscles
Comparison
alpha-human atrial natriuretic polypeptide vs control conditions without alpha-hANP
Design
Preclinical
Authors
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Should not change practice from rat aorta data; leaves open Na,K-pump mediation of ANP effects in humans.
The vasodilating effect of alpha-hANP in rat aorta is at least partially mediated by the activation of the electrogenic Na, K-pump, particularly when the pump is partially suppressed.
Sato et al. (1988) studied this question.
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