Population
Isolated vessels from the pulmonary and mesenteric/omental arterial circulations of rabbit and man
Design
Preclinical
Authors
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May guide research on ANP-based pulmonary hypertension therapies; leaves open translation from ex vivo vessels to clinical use.
Alpha-hANP demonstrates a relatively selective vasodilatory effect on pulmonary arterial vessels in both rabbits and humans, suggesting a role in regulating pulmonary vascular tone.
Lindberg et al. (1988) studied this question.
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