Key result
ANP induces concentration-dependent relaxation with profound regional selectivity in isolated monkey arteries and veins.
Why the study?
Regional differences in vasorelaxant responses of isolated monkey arteries and veins to atrial natriuretic peptide were not well characterized.
Population
Isolated monkey arteries and veins
Comparison
Atrial natriuretic peptide (rat and human) vs sodium nitroprusside
Design
Preclinical study recording isometric tension
Authors
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ANP regional selectivities in primate vessels are hypothesis-generating; extends preclinical models but leaves open human translation.
Atrial natriuretic peptide exhibits profound regional vasorelaxant selectivities in isolated monkey arteries and veins.
Kawai et al. (1989) studied this question. Atrial natriuretic peptide was evaluated on Relaxation in isolated monkey arteries and veins. Atrial natriuretic peptide produced concentration-dependent relaxation in isolated monkey arteries and veins, demonstrating profound regional vasorelaxant selectivities.
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