Key result
Alpha-human natriuretic polypeptide relaxes preconstricted canine vascular strips, with the greatest effect in the pulmonary artery.
Why the study?
The vasorelaxant effects of alpha-human atrial natriuretic polypeptide vary across different vascular regions in dogs and require characterization.
Does alpha-human natriuretic polypeptide induce vasorelaxation in isolated canine vascular strips?
Does alpha-human natriuretic polypeptide induce vasorelaxation in isolated canine vascular strips?
Alpha-human natriuretic polypeptide induces heterogeneous vasorelaxation in canine vessels, with the most pronounced effect in the pulmonary artery.
Answers are grounded in this paper and cite their sources.
Should not change practice; leaves open selective pulmonary vascular effects pending in vivo studies.
Effects of alpha-human natriuretic polypeptide (ANP) on isolated canine vascular strips were examined in 6 arteries and 5 veins. Under the preconstriction with either methoxamine, prostaglandin F2 alpha or KCl, ANP relaxed the vascular strips to various degrees, depending on the region removed from the circulatory system. The largest relaxation was obtained in the pulmonary artery, suggesting that the pulmonary artery may be an important site of action of ANP.
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Ishikawa et al. (1987) studied this question. alpha-human natriuretic polypeptide (ANP) was evaluated on Vasorelaxation of vascular strips. Alpha-human natriuretic polypeptide relaxed preconstricted canine vascular strips to various degrees, with the largest relaxation observed in the pulmonary artery.
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