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December 1, 1981Circulation ResearchOpen Access

Influence of diabetes on the myocardium and coronary arteries of rhesus monkey fed an atherogenic diet.

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Why the study?

Does diabetes influence the progression of coronary atherosclerosis and primary myocardial alterations in rhesus monkeys fed an atherogenic diet?

Population

Rhesus monkeys (nondiabetic and alloxan-induced diabetic models)

Comparison

Alloxan-induced diabetes combined with either a… vs Nondiabetic monkeys fed either a standard or…

Design

Preclinical

Follow-up

18 months

Authors

BHB HaiderQueen Fabiola Children's University HospitalCYChien K. YehRutgers New Jersey Medical SchoolGTGiles ThomasActelion (Switzerland)

Discussion

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Overview

No synergy between diabetes and hypercholesterolemia on early primate lesions; leaves open interactions in advanced human disease.

Key Points

  • To evaluate the impact of alloxan-induced diabetes on primary myocardial alterations and the progression of diet-induced coronary atherosclerosis in rhesus monkeys.
  • Rhesus monkeys were maintained for 18 months across 4 experimental groups: nondiabetic control diet (group 1), nondiabetic atherogenic diet (group 2), diabetic control diet (group 3), and diabetic atherogenic diet (group 4).
  • Cardiac function was assessed under anesthesia via indicator dilution and saline-induced preload elevation, alongside myocardial hydroxyproline quantification, electron microscopy, and coronary artery cholesterol measurement.
  • Diabetic monkeys demonstrated impaired stroke work responses to saline loading and significantly higher rises in left ventricular end-diastolic pressure (from 10.1 ± 1.4 to 20.5 ± 2.7 mm Hg in group 3; from 11.1 ± 2.1 to 24.0 ± 3.3 mm Hg in group 4) alongside reduced end-diastolic volume expansion compared to nondiabetic controls.
  • Myocardial hydroxyproline content rose markedly in diabetic animals (8.4 ± 0.35 g/mg in group 3 and 7.1 ± 0.37 g/mg in group 4 vs. 4.98 ± 0.33 in group 1 and 5.16 ± 0.24 in group 2), driven by an increase in insoluble collagen between myofibers that enhanced wall stiffness.
  • Coronary artery cholesterol content was similarly elevated between nondiabetic (plasma cholesterol 367 ± 55 mg/100 ml) and diabetic (408 ± 62 mg/100 ml) monkeys on atherogenic diets, showing diabetes did not accelerate early lipid streak formation.

Structured PICO

Does diabetes influence the progression of coronary atherosclerosis and primary myocardial alterations in rhesus monkeys fed an atherogenic diet?

P
Population
Rhesus monkeys (nondiabetic and alloxan-induced diabetic models)
I
Intervention
Alloxan-induced diabetes combined with either a standard (Purina) or atherogenic diet
C
Comparator
Nondiabetic monkeys fed either a standard (Purina) or atherogenic diet
O
Outcome
Progression of coronary atherosclerosis (measured by coronary artery cholesterol content) and primary myocardial alterations (hemodynamics, contractility, and collagen content)surrogate

This preclinical study suggests that diabetes independently causes myocardial stiffening through collagen deposition but does not synergistically worsen early coronary atherosclerosis induced by an atherogenic diet in rhesus monkeys.

Cite This Study

Haider et al. (1981) studied this question.

synapsesocial.com/papers/6a87dadde6314279fbfb1157https://doi.org/10.1161/01.res.49.6.1278

Topics

Sermorelin
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Also Consider

Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Evidence for Cardiomyopathy in Familial Diabetes Mellitus1977 · 736 citations
  2. 2Hyperglycemia and Plasma Lipid Levels1980 · 192 citations