Population
Mice infected with tissue culture-adapted Theiler's murine encephalomyelitis virus (WW strain) (TMEV-WW)
Comparison
Infection with tissue culture-adapted TMEV-WW vs Brain-derived TMEV-WW-infected mice
Design
Preclinical
Follow-up
Up to 78 days post-inoculation
Authors
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Animal model findings on TMEV tropism should not inform clinical practice; leaves open relevance to human demyelinating disease.
The study demonstrates that tissue culture-adapted TMEV-WW exhibits nearly exclusive spinal cord white matter tropism, which correlates directly with its disease-inducing potential in mice.
Stroop et al. (1982) studied this question.
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