Why the study?
Does preoperative ACE inhibitor therapy decrease systemic vascular resistance and increase vasoactive drug requirements in adult patients undergoing hypothermic cardiopulmonary bypass?
Population
62 adult patients undergoing cardiac surgical procedures requiring hypothermic cardiopulmonary bypass
Comparison
Preoperative angiotensin converting enzyme… vs No preoperative ACE inhibitor therapy
Design
Cohort, Doctor administering vasoactive drugs was unaware of the nature of the…
Follow-up
Immediate post-bypass period
Authors
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Hypothesis-generating for increased vasoactive needs with preoperative ACE inhibitors; randomized trials needed before changing practice.
Does preoperative ACE inhibitor therapy decrease systemic vascular resistance and increase vasoactive drug requirements in adult patients undergoing hypothermic cardiopulmonary bypass?
Preoperative ACE inhibitor therapy is associated with decreased systemic vascular resistance and an increased need for vasoactive support during and immediately after hypothermic cardiopulmonary bypass.
Charles D. Deakin (1998) studied this question.
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