Population
Nephrectomized dogs
Design
Preclinical
Follow-up
3 hours
Authors
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Should not guide human renin kinetics; leaves open translational validity of biphasic clearance to endogenous renin in patients.
Exogenous renin disappears from the plasma of nephrectomized dogs in a biphasic manner, with half-times of 6 and 79 minutes, suggesting a similar half-time for endogenous renin.
Assaykeen et al. (1968) studied this question.