Population
Homogeneous recombinant HDL particles containing apoA-I, palmitoyl-oleoyl phosphatidylcholine and…
Comparison
Varying POPC content and particle shape vs Free apoA-I in solution or different particle…
Design
Preclinical
Authors
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Indicates particle-specific apoA-I charge; extends HDL structural models but leaves open in vivo metabolic effects.
Different HDL subspecies maintain particular apoA-I conformations that confer unique charge and structural characteristics, which likely modulate HDL metabolism and cholesterol transport.
Sparks et al. (1992) studied this question.
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