Why the study?
Does dobutamine alter the oxygen cost of left ventricular contractility compared to calcium in normal and failing rat hearts?
Population
Normal rat hearts and Ca2+ overload-induced failing rat hearts
Comparison
Dobutamine vs Calcium (Ca2+)
Design
Preclinical
Authors
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No difference in rat model energetics; leaves open whether dobutamine preserves Ca2+ sensitivity in human HF.
Does dobutamine alter the oxygen cost of left ventricular contractility compared to calcium in normal and failing rat hearts?
The oxygen cost of left ventricular contractility for dobutamine in calcium overload-induced failing rat hearts does not differ significantly from that in normal hearts, suggesting no changes in the sensitivity of the contractile machinery for Ca2+.
Tabayashi et al. (2002) studied this question.
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