October 1, 1988AJP Heart and Circulatory Physiology

No significant increase in O2 consumption of KCl-arrested dog heart with filling and dobutamine

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Why the study?

Does dobutamine or left ventricular volume change resting oxygen consumption in KCl-arrested dog hearts?

Population

Cross-circulated dog hearts arrested with KCl

Comparison

Dobutamine continuous infusion at 10-25… vs Control

Design

Preclinical

Authors

TNTakashi NozawaKyoto University YYYoshio YasumuraHeart Failure / Cardiomyopathy SFShiho FutakiJuntendo University Hospital

Discussion

Member takes

Implication

Basal MVO2 stability in arrested dog hearts warrants no clinical change; leaves open translation to human cardioplegia or energetics.

Structured PICO

Does dobutamine or left ventricular volume change resting oxygen consumption in KCl-arrested dog hearts?

Population

Cross-circulated dog hearts arrested with KCl

Intervention

Dobutamine continuous infusion at 10-25 micrograms/min and changes in left ventricular volume

Comparator

Control (no dobutamine, baseline left ventricular volume)

Outcome

Resting oxygen consumption (MVO2)surrogate

Myocardial oxygen consumption for basal metabolism in a working dog heart remains virtually constant regardless of ventricular volume and contractility.

Cite This Study

Nozawa et al. (1988) studied this question.

synapsesocial.com/papers/6a87f10bfa9d1f0cc6582661 https://doi.org/10.1152/ajpheart.1988.255.4.h807

View Full Paper

Ask AI

Bookmark

No significant increase in O2 consumption of KCl-arrested dog heart with filling and dobutamine

Discussion

Member takes

Implication

Structured PICO

Cite This Study

No significant increase in O2 consumption of KCl-arrested dog heart with filling and dobutamine

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider