Why the study?
Does morphine infusion compared to fentanyl infusion increase histamine release and cause hypotension in patients prior to coronary artery bypass surgery?
Population
15 patients prior to coronary artery bypass surgery
Comparison
Morphine infusion [n=8] vs Fentanyl infusion [n=7]
Design
RCT, randomized
Authors
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Fentanyl should be preferred over morphine for CABG induction to avoid hypotension; confirms morphine's histamine-mediated vasodilatory effects in this setting.
Does morphine infusion compared to fentanyl infusion increase histamine release and cause hypotension in patients prior to coronary artery bypass surgery?
Morphine, unlike fentanyl, induces significant histamine release leading to peripheral vasodilation and hypotension during anesthesia induction for CABG.
Rosow et al. (1982) studied this question.
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