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April 1, 1994Clinical and Experimental Pharmacology and PhysiologyOpen Access

A New Restriction Fragment Length Polymorphism in the First Intron of the Spontaneously Hypertensive Rat Renin Gene

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Population

Spontaneously hypertensive rat (SHR), Wistar-Kyoto (WKY) and Sprague-Dawley rats (SD) models

Comparison

Amplification of the entire first intron of the… vs Comparison between rat strains (SHR, WKY, SD)

Design

Preclinical

Authors

DWD. Z‐M. WangThe University of MelbourneAWAndrew F. WilksBoston UniversityTMT. O. MorganThe University of Melbourne

Discussion

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Implication

Does not inform clinical hypertension care; leaves open functional role of SHR renin intron deletion in pathogenesis.

Structured PICO

P
Population
Spontaneously hypertensive rat (SHR), Wistar-Kyoto (WKY) and Sprague-Dawley rats (SD) models
I
Intervention
Amplification of the entire first intron of the renin gene followed by Bgl II digestion
C
Comparator
Comparison between rat strains (SHR, WKY, SD)
O
Outcome
Identification of restriction fragment length polymorphism (RFLP) and tandem repeat element length differencessurrogate

The identification of a new restriction fragment length polymorphism in the first intron of the renin gene in spontaneously hypertensive rats suggests a potential genetic mechanism for renin overexpression in this model.

Cite This Study

Wang et al. (1994) studied this question.

synapsesocial.com/papers/6a880170ab77196d53aa65cahttps://doi.org/10.1111/j.1440-1681.1994.tb02524.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A major structural abnormality in the renin gene of the spontaneously hypertensive rat1989 · 45 citations
  2. 2Analysis of the renin gene intron A tandem repeat region of Milan and Lyon hypertensive rat strains1990 · 17 citations
  3. 3Structural Differences in the Renin Gene of Dahl Salt-Sensitive and Salt-Resistant Rats1989 · 27 citations
  4. 4A Widespread Abnormality of Renin Gene Expression in the Spontaneously Hypertensive Rat: Modulation in Some Tissues with the Development of Hypertension1989 · 48 citations
  5. 5A Genetic Polymorphism in the Renin Gene of Dahl Rats Cosegregates with Blood Pressure1989 · 294 citations