September 1, 1990Journal of Hypertension
Analysis of the renin gene intron A tandem repeat region of Milan and Lyon hypertensive rat strains
Population
Milan and Lyon hypertensive rat strains and their controls (MNS, LN, LL), and several Sprague-Dawley rats
Comparison
Analysis of the region of intron A of the rat… vs Normotensive control strains (MNS, LN, LL)
Design
Preclinical
Authors
Discussion
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Implication
Tandem repeat in rat renin intron not major BP driver; leaves open other genetic factors in hypertensive strains.
Structured PICO
P
Population
Milan and Lyon hypertensive rat strains and their controls (MNS, LN, LL), and several Sprague-Dawley rats
I
Intervention
Analysis of the region of intron A of the rat renin gene containing a unique tandemly repeated sequence using an oligonucleotide probe and a renin complementary DNA probe
C
Comparator
Normotensive control strains (MNS, LN, LL)
O
Outcome
Size of the Bgl II DNA fragment encompassing the tandem repeat regionsurrogate
The tandem repeat region of intron A in the rat renin gene does not appear to be a major cause of blood pressure differences in the Lyon hypertensive rat model.
Cite This Study
Samani et al. (1990) studied this question.