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January 1, 1998Clinical and Experimental HypertensionOpen Access

Nucleotide Variations in Intron 1 of the Renin Gene of the Spontaneously Hypertensive Rat

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Population

Spontaneously hypertensive rat of the Okamoto strain, and Wistar Kyoto and Sprague Dawley normotensive rats

Comparison

Sequence analysis of the first 1,100 base pairs… vs WKY and SD normotensive rats

Design

Preclinical

Authors

RNR. Di NicolantonioNovartis (Spain)LLLing LanHenan Provincial People's HospitalAWAndrew F. WilksBoston University

Discussion

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Implication

Findings in rat models remain hypothesis-generating; does not alter clinical hypertension management and warrants human genetic validation.

Structured PICO

P
Population
Spontaneously hypertensive rat (SHR) of the Okamoto strain, and Wistar Kyoto (WKY) and Sprague Dawley (SD) normotensive rats
I
Intervention
Sequence analysis of the first 1,100 base pairs of the first intron of the renin gene
C
Comparator
WKY and SD normotensive rats
O
Outcome
Mutations in putative transcriptional factor binding sites in the first intron of the renin genesurrogate

Specific mutations in the first intron of the renin gene in spontaneously hypertensive rats may alter transcriptional factor binding, potentially explaining the overexpression of the renin gene and subsequent hypertension.

Cite This Study

Nicolantonio et al. (1998) studied this question.

synapsesocial.com/papers/6a8801ca4a20e1705414b76ahttps://doi.org/10.3109/10641969809053204

Topics

Hypertension management
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Structural alterations of the renin gene in stroke-prone spontaneously hypertensive rats: examination of genotype-phenotype correlations1990 · 65 citations
  2. 2Analysis of the renin gene intron A tandem repeat region of Milan and Lyon hypertensive rat strains1990 · 17 citations
  3. 3Altered age-dependent modulation of tissue renin messenger RNA levels in the spontaneously hypertensive rat1996 · 26 citations
  4. 4A Genetic Polymorphism in the Renin Gene of Dahl Rats Cosegregates with Blood Pressure1989 · 294 citations
  5. 5MUTATIONS IN THE FIRST INTRON OF THE SHR RENIN GENE DISRUPT PUTATIVE REGULATORY ELEMENTS1995 · 10 citations