Why the study?
Does caffeine combined with psychological stress increase ACTH and cortisol levels in men at high and low risk for hypertension?
Population
Men at high risk versus low risk for hypertension
Comparison
Caffeine alone and combined with behavioral stress vs Placebo (caffeine-placebo crossover design)
Design
RCT, Randomized crossover design, Double-blind
Follow-up
Four test sessions held on separate days
Authors
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May warrant caffeine caution during stress for high-risk men; extends RCT evidence on differential cortisol responses by hypertension risk.
Does caffeine combined with psychological stress increase ACTH and cortisol levels in men at high and low risk for hypertension?
Caffeine combined with psychological stress elevates ACTH and cortisol, with more pronounced and persistent effects in men at high risk for hypertension.
Al’Absi et al. (1998) studied this question.
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