Why the study?
Does oxprenolol compared to nitrendipine improve ambulatory blood pressure in middle-aged male patients with essential hypertension?
Does oxprenolol compared to nitrendipine improve ambulatory blood pressure in middle-aged male patients with essential hypertension?
Oxprenolol and nitrendipine are equally effective as baseline antihypertensive monotherapy in middle-aged men, although oxprenolol may provide lower systolic blood pressure during physical activity and arousal.
Does not support superiority for ambulatory BP control; leaves open activity-specific effects for randomized confirmation.
We investigated whether beta-blockers or calcium-antagonists might be preferred in baseline antihypertensive therapy. In middle-aged male patients with essential BP readings did not differ between patients on Oxprenolol or on Nitrendipine (average BP: 123 +/- 12/81 +/- 14 vs. 129 +/- 17/80 +/- 10 mmHg), when clinical casual BP was within the normotensive range. Average BP at work was lower than clinical casual BP taken at the same day (125 +/- 14/80 +/- 12 vs. 133 +/- 12/87 +/-13 mmHg). A linear dependency between SBP at work and level of self reported physical activity (F(3,413) = 7.6; p less than or equal to 0.001) and arousal was found (F(3,374) = 5.2; p less than or equal to 0.02). Patients on Oxprenolol consistently had lower SBP at a particular level of physical activity and at lower levels of arousal than patients on Nitrendipine. We conclude that both regimen were equally effective as baseline antihypertensive monotherapy.
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Schmieder et al. (1985) studied this question.
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