Population
Primary cultures of endothelial cells obtained from human umbilical vein, porcine aorta and bovine carotid…
Comparison
Endothelin isopeptides vs Basal values, histamine, bradykinin, and sodium…
Design
Preclinical
Authors
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Endothelin isopeptides lack direct effects on endothelial NO or PGI2 release in vitro; leaves open receptor coupling in vivo or disease states.
Endothelin isopeptides do not stimulate the release of NO or PGI2 from primary cultures of human, porcine, or bovine endothelial cells, suggesting a lack of coupled endothelin receptors for these pathways in these cells.
White et al. (1993) studied this question.
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