Why the study?
Do venous endothelial cells have a similar capacity to arterial endothelial cells to release vasoactive factors?
Population
Endothelial cells (EC) cultured from either bovine vena cava (BVCEC) or bovine aorta (BAEC)
Comparison
Stimulation with Bradykinin, arachidonic acid… vs Comparison between venous and arterial…
Design
Preclinical
Authors
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Indicates venous endothelium may modulate tone; leaves open translation from bovine cells to human physiology.
Do venous endothelial cells have a similar capacity to arterial endothelial cells to release vasoactive factors?
Venous endothelial cells demonstrate a similar capacity to arterial endothelial cells in releasing vasoactive factors, suggesting veins possess a functional endothelium that modulates venous tone.
D’Orléans-Juste et al. (1992) studied this question.
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