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November 12, 2008BloodOpen Access

beta3(Delta760-762) mice were protected from carotid artery thrombosis after vessel injury with FeCl3 compared to control mice, without demonstrating spontaneous bleeding.

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Why the study?

Does targeting alphaIIbbeta3 signaling by deleting beta3 RGT prevent arterial thrombosis in mice?

Population

Mouse model (beta3(Delta760-762) knockin mice)

Comparison

Genetic deletion of beta3 RGT vs Wild-type beta3 littermates, beta3…

Design

Preclinical

Authors

AAArarat J. AbloogluJKJian KangBPBrian G. Petrich

Discussion

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Overview

May guide selective antiplatelet development; leaves open translation to human thrombosis prevention without bleeding.

Structured PICO

Does targeting alphaIIbbeta3 signaling by deleting beta3 RGT prevent arterial thrombosis in mice?

P
Population
Mouse model (beta3(Delta760-762) knockin mice)
I
Intervention
Genetic deletion of beta3 RGT (disrupting c-Src-mediated alphaIIbbeta3 signaling)
C
Comparator
Wild-type beta3(+/+) littermates, beta3(+/-) heterozygotes, and knockin mice where beta3 RGT was replaced by beta1 C-terminal cysteine-glycine-lysine (EGK)
O
Outcome
Carotid artery thrombosis after vessel injury with FeCl3surrogate

Disrupting c-Src-mediated alphaIIbbeta3 signaling by deleting beta3 RGT confers protection from arterial thrombosis without causing spontaneous bleeding, suggesting a potential novel antithrombotic strategy.

Cite This Study

Ablooglu et al. (2008) studied this question.

synapsesocial.com/papers/6a881145afcf99b77fbbf6ebhttps://doi.org/10.1182/blood-2008-09-180687
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