Key result
Coronary flow reserve by contrast-enhanced echocardiography detected cardiac allograft vasculopathy with 87% specificity and 82% sensitivity at an optimal cut point of ≤2.7.
Why the study?
Does coronary flow reserve assessment by contrast-enhanced echocardiography accurately detect cardiac allograft vasculopathy in heart transplant recipients?
Population
73 heart transplant (HT) recipients (59 male, aged 50+/-12 years at HT), assessed at 8+/-4.5 years post-HT.
Comparison
Coronary flow reserve assessment in the left… vs Coronary angiography.
Design
Cross-sectional, CFR measurements were taken blindly from coronary…
Authors
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May support noninvasive CAV screening by contrast-enhanced echocardiography in transplant recipients; leaves open prospective validation before practice change.
Observational (n=73)
Single-blind
Does coronary flow reserve assessment by contrast-enhanced echocardiography accurately detect cardiac allograft vasculopathy in heart transplant recipients?
p-value: p=<0.0001
Coronary flow reserve assessment by contrast-enhanced echocardiography using a cut point of <=2.7 is an accurate noninvasive tool for detecting cardiac allograft vasculopathy.
Tona et al. (2006) conducted an observational in Cardiac allograft vasculopathy (n=73). Coronary flow reserve by contrast-enhanced transthoracic echocardiography vs. Coronary angiography was evaluated on Detection of cardiac allograft vasculopathy (p=<0.0001). Coronary flow reserve by contrast-enhanced echocardiography detected cardiac allograft vasculopathy with 87% specificity and 82% sensitivity at an optimal cut point of ≤2.7.
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