Why the study?
Does thrombomodulin modulate thrombin-induced ERK phosphorylation and nuclear retention in endothelial cells?
Population
Human umbilical vein endothelial cells (HUVECs)
Comparison
Thrombin, thrombin receptor-activating peptide… vs Different agonists and inhibitors compared…
Design
Preclinical
Follow-up
Up to 4 hours
Authors
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Does not inform therapy; extends thrombomodulin beyond coagulation to thrombin-ERK signaling in animal endothelial cells.
Does thrombomodulin modulate thrombin-induced ERK phosphorylation and nuclear retention in endothelial cells?
Thrombomodulin acts as a thrombin receptor that modulates the duration of ERK nuclear retention and cell proliferation in endothelial cells, extending its known role beyond blood coagulation.
Olivot et al. (2001) studied this question.
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