Why the study?
Does the local effect of angiotensin II on the renal vascular bed contribute to hypertension in rats with aortic constriction?
Does the local effect of angiotensin II on the renal vascular bed contribute to hypertension in rats with aortic constriction?
This preclinical study demonstrates that the kidneys and local angiotensin II effects play a major role in the development of hypertension following proximal aortic constriction.
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Supports local renal angiotensin II in experimental hypertension models; leaves open translation to human aortic disease.
SAHLGREN et al. (1986) studied this question.
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