Population
Madin-Darby canine kidney (MDCK) cell line, proximal tubule-derived LLC-PK1 cells, and opossum kidney cells
Comparison
Hyperosmotic culture conditions using NaCl… vs Isosmotic culture conditions
Design
Preclinical
Follow-up
up to 48 hours
Authors
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Hypothesis-generating for solute-specific ET regulation in renal cells; in vivo studies needed before any clinical relevance.
Hyperosmolality regulates endothelin release in MDCK cells differently depending on the solute used, with NaCl and raffinose decreasing and urea increasing production.
Schramek et al. (1993) studied this question.
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