Why the study?
Are allograft rejection episodes, CMV infection, or hyperlipidaemia associated with the development of graft coronary artery disease after heart transplantation?
Population
73 heart transplant recipients at a single centre who survived at least 2 years post-transplant.
Design
Cohort
Follow-up
at least 2 years (up to 5 years)
Authors
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Frequent early rejections may prompt closer TxCAD surveillance; supports the rejection-TxCAD link but leaves open whether prevention alters outcomes.
Are allograft rejection episodes, CMV infection, or hyperlipidaemia associated with the development of graft coronary artery disease after heart transplantation?
Frequent episodes of allograft rejection in the first year are associated with the development of advanced graft coronary artery disease after heart transplantation.
Scott et al. (1992) studied this question.
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