Key result
Higher donor age (P<0.001) and recipient body mass index (P=0.003) were significant risk factors for early allograft coronary artery disease development after orthotopic heart transplantation.
Why the study?
What are the risk factors for the early development of allograft coronary artery disease in orthotopic heart transplantation recipients?
Observational (n=83)
What are the risk factors for the early development of allograft coronary artery disease in orthotopic heart transplantation recipients?
p-value: p=<0.001 for donor age, 0.003 for recipient BMI
Higher donor age and recipient body mass index are significant independent risk factors for the very early development of allograft coronary artery disease following heart transplantation.
May inform donor-recipient matching and counseling; leaves open whether interventions mitigate early allograft vasculopathy risk.
Orthotopic heart transplantation (OHTx) represents a well established method of end-stage heart failure treatment. Allograft coronary artery disease (CAD) still remains to be one of the most important limiting factors for OHTx recipients' long-term survival. Unfortunately, allograft CAD can be detected very early after OHTx. Our study was designed to identify risk factors for early allograft CAD development. Eighty-three OHTx recipients (18 females, 65 males, mean age 50.55 +/- 11.04 years) with coronary intravascular ultrasound examination performed early after OHTx (29.81 +/- 12.45 days) formed the study population. The impact of a number of pre-, peri- and early post-transplant possible risk factors on early allograft CAD development was studied. By multivariate analysis, only higher donor age (P < 0.001) and higher recipient's body mass index (P = 0.003) were found to represent risk factors for the early development of allograft CAD.
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Kocik et al. (2007) conducted an observational in Orthotopic heart transplantation (n=83). Pre-, peri- and early post-transplant risk factors was evaluated on Early development of allograft CAD (p=<0.001 for donor age, 0.003 for recipient BMI). Higher donor age (P<0.001) and recipient body mass index (P=0.003) were significant risk factors for early allograft coronary artery disease development after orthotopic heart transplantation.
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