Key result
Cardiac transplantation between genetically similar rats resulted in transplant coronary artery disease in 97.8% of grafts, occurring in the absence of a cellular alloimmune response.
Population
Inbred lean Zucker rats serving as donors and recipients of cardiac grafts
Comparison
Cardiac transplantation between genetically… vs Native hearts
Design
Preclinical
Follow-up
60 or 90 days
Authors
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Supports non-immune mechanisms in transplant CAD; leaves open their relevance to human allograft outcomes.
Absolute Event Rate: 97.8% vs 0%
Transplant coronary artery disease can develop independently of a cellular alloimmune response, suggesting other mechanisms contribute to its pathogenesis.
Cantin et al. (2001) studied Transplant Coronary Artery Disease (n=46). Cardiac transplantation vs. Native hearts was evaluated on Development of transplant coronary artery disease (TxCAD). Cardiac transplantation between genetically similar rats resulted in transplant coronary artery disease in 97.8% of grafts, occurring in the absence of a cellular alloimmune response.
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