Key result
Functional capillary rarefaction measures were significantly lower in both treated and untreated high blood pressure groups compared to normotensives, and correlated inversely with endothelial function.
Why the study?
Is capillary rarefaction detectable and associated with endothelial dysfunction in persons with mild systolic blood pressure elevation?
Cross-Sectional (n=150)
Is capillary rarefaction detectable and associated with endothelial dysfunction in persons with mild systolic blood pressure elevation?
Answers are grounded in this paper and cite their sources.
Functional capillary rarefaction and endothelial dysfunction are present even at modest levels of blood pressure elevation, indicating early vascular pathology.
This study aimed to determine if capillary rarefaction is detectable and associated with endothelial dysfunction in persons with mild systolic blood pressure (SBP) elevation. Capillary density and endothelial function were quantified for 150 nondiabetic participants, grouped by blood pressure (BP) as normotensive, untreated high BP, and treated high BP. Structural capillary rarefaction measures were not different between the three groups. Functional capillary rarefaction measures were significantly lower in both high BP groups compared to normotensives, and correlated inversely with endothelial function. The study findings indicate that the hypertensive vascular pathologic process is already underway at modest levels of blood pressure elevation.
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Cheng et al. (2008) conducted a cross-sectional in Mild systolic blood pressure elevation (n=150). High blood pressure (treated and untreated) vs. Normotensive was evaluated on Structural and functional capillary rarefaction measures and endothelial function. Functional capillary rarefaction measures were significantly lower in both treated and untreated high blood pressure groups compared to normotensives, and correlated inversely with endothelial function.
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