Why the study?
Does experimental chronic alcoholism alter the morphology and biomechanics of the abdominal aorta in Wistar rats?
Does experimental chronic alcoholism alter the morphology and biomechanics of the abdominal aorta in Wistar rats?
Experimental chronic alcoholism in a rat model increases aortic elongation without causing morphological alterations in the aortic wall.
Chronic alcoholism may alter aortic biomechanics in rats; leaves open any human relevance and requires translational studies.
PURPOSE: To assess the influence of experimental chronic alcoholism in the morphology and biomechanics of the aorta, in a rat model. METHODS: Forty-four Wistar rats were randomly divided into two groups of 22 animals each: in the alcoholism group, the rats received water mixed to increasing concentrations of ethyl alcohol; and control group: the rats received pure water for 180 days. The animals were then killed by an overdose of pentobarbital and the abdominal aortas were excised for histological (hematoxylin-eosin, Masson, Calleja, and Picrosirius red stain), histomorphometrical, and biomechanical analysis. RESULTS: Histology and histomorphometry did not show differences in aorta morphology of both groups. Biomechanical analysis showed a significantly greater yield point elongation in the alcoholic rat group (p < 0.05). CONCLUSION: Chronic alcoholism did not cause morphological alterations in the aortic wall but increased elongation, without modifying any other mechanical properties.
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Cerqueira et al. (2005) studied this question.
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