Why the study?
Are haplotypes of the beta2-adrenergic receptor gene associated with essential hypertension in a Singaporean Chinese population?
Are haplotypes of the beta2-adrenergic receptor gene associated with essential hypertension in a Singaporean Chinese population?
Variants at the beta2-adrenergic receptor (B2AR) locus may play a role in the pathophysiology of essential hypertension in the Singaporean Chinese population.
Supports possible B2AR haplotype association with hypertension in Singaporean Chinese; hypothesis-generating and requires prospective validation before any clinical inference.
OBJECTIVE: To investigate the relation between the gene encoding the beta2-adrenergic receptor (B2AR) and essential hypertension in a Singaporean Chinese cohort. METHODS: Three single nucleotide polymorphisms (SNPs) were genotyped in 190 cases and 323 controls, and eight haplotypes were determined and tested for association using the likelihood test statistic. RESULTS: We observed a significant difference in haplotype frequency distributions between the cases and the controls (P <0.00001). A logistic regression model fitted to the data supported this finding. CONCLUSION: The results suggest that variants at the B2AR locus may play a role in the pathophysiology of hypertension in this population.
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Lee et al. (2004) studied this question.
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