Why the study?
Do dopamine and its agonists (SK&F 38393, bromocriptine) have differential vasodilator effects on renal and coronary vascular beds in anaesthetized dogs?
Population
Anaesthetized dogs
Design
Preclinical
Authors
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Hypothesis-generating for distinct dopamine receptor subtypes across vascular beds; leaves open translation to selective human therapies.
Do dopamine and its agonists (SK&F 38393, bromocriptine) have differential vasodilator effects on renal and coronary vascular beds in anaesthetized dogs?
The selective renal vasodilatation by SK&F 38393 suggests that dopamine receptors in the renal and coronary vascular beds may be of different subtypes.
Lang et al. (1982) studied this question.
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