Population
Xenopus oocytes
Comparison
Injection of recombinant coxsackievirus B4… vs Absence of intact eIF4G / control conditions
Design
Preclinical
Follow-up
6-12 hours
Authors
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Supports cap-independent translation in oocytes; leaves open its relevance to protein synthesis in mammalian cardiomyocytes.
This study demonstrates that translation initiation of most endogenous mRNAs in Xenopus oocytes can proceed via a cap-independent mechanism despite the cleavage of eIF4G.
Brett D. Keiper (1997) studied this question.
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