Population
Single cardiac myocytes isolated from hypothyroid, euthyroid, and hyperthyroid rats, and Langendorff…
Comparison
Hyperthyroid state vs Hypothyroid and euthyroid states
Design
Preclinical
Authors
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Thyroid-induced shifts in myocyte pH and Na+ may modulate contractility; leaves open relevance to human cardiac disease.
Changes in cardiac contractility associated with altered thyroid state may involve changes in the response of myofilaments to intracellular Ca2+ mediated by altered intracellular pH and Na+.
Wolska et al. (1997) studied this question.
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