Collagen Metabolism in Extracellular Matrix May Be Involved in Arterial Stiffness in Older Hypertensive Patients with Left Ventricular Hypertrophy
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Key result
Arterial stiffness assessed by brachial-ankle pulse wave velocity was significantly correlated with the total TIMP-1/MMP-1 ratio (r=0.38, p<0.05) in older hypertensive patients with left ventricular hypertrophy.
Population
46 older hypertensive patients with left ventricular hypertrophy detected by electrocardiography or…
Design
Cross-sectional
Authors
Discussion
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Implication
Supports matrix remodeling link to stiffness in hypertensive LVH; hypothesis-generating and requires longitudinal confirmation before clinical consideration.
Study Design
Type
Cross-Sectional (n=46)
Multicenter
No
Structured PICO
P
Population
46 older medicated hypertensive patients with left ventricular hypertrophy (mean age 71.3 years, 37% female) evaluated for the association between arterial stiffness and extracellular matrix collagen metabolism.
O
Outcome
Correlation between brachial-ankle pulse wave velocity (baPWV) and plasma levels of collagen metabolism markers (PICP, ICTP, MMP-1, TIMP-1, and total TIMP-1/MMP-1 ratio)surrogate
Main Result
Effect estimate: r=0.38
p-value: p=<0.05
Arterial stiffness, as measured by brachial-ankle pulse wave velocity, is significantly correlated with extracellular matrix collagen turnover independently of blood pressure in older hypertensive patients with left ventricular hypertrophy.
Limitations
- Cross-sectional design provides little prognostic data about baPWV for the risk of cardiovascular events.
- Patients were on antihypertensive medications, and the interaction of these drugs with collagen metabolism could not be completely excluded.
- The total TIMP-1/MMP-1 ratio was measured instead of the free form complex.
- Patients were medicated and the interaction of antihypertensive drugs could not be completely excluded
- Little prognostic data exists regarding baPWV as a prognostic factor for the risk of cardiovascular events
Cite This Study
Ishikawa et al. (2005) conducted a cross-sectional in Hypertension with left ventricular hypertrophy (n=46). Collagen metabolism markers (total TIMP-1/MMP-1 ratio) was evaluated on Correlation between brachial-ankle pulse wave velocity (baPWV) and total TIMP-1/MMP-1 ratio adjusted for confounding factors (r=0.38, p=<0.05). Arterial stiffness assessed by brachial-ankle pulse wave velocity was significantly correlated with the total TIMP-1/MMP-1 ratio (r=0.38, p<0.05) in older hypertensive patients with left ventricular hypertrophy.
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