Key result
Untreated essential hypertension in males is linked to ~50% higher carotid intima media thickness.
Why the study?
Increased intima media thickness and left ventricular mass index are independent vascular risk factors potentially linked to altered collagen metabolism in hypertension.
Observational (n=64)
Absolute Event Rate: 0.6% vs 0.4%
p-value: p=<0.001
Elevated TIMP-1 in untreated hypertension may signal early remodeling risk; leaves open whether modulating collagen turnover alters vascular outcomes.
BACKGROUND: Increased intima media thickness (IMT) of common carotid arteries (CCAs) and left ventricular mass index (LVMI) are independent risk factors for vascular events and may be related to accumulation of extracellular proteins due to altered metabolism of collagen. METHODS: IMT and LVMI were measured ultrasonographically in 50 males with newly diagnosed, untreated, essential hypertension (HTN, 37.7 +/- 13.1 years), and 14 controls (C, 32.6 +/- 9.7 years). Serum levels of procollagen type I carboxy-terminal propeptide (PICP), procollagen type III amino-terminal propeptide (PIIINP), carboxy-terminal telopeptide (ICTP), matrix metalloproteinase (MMP-1) and tissue inhibitor of metalloproteinase-1 (TIMP-1) were determined using immunoassays. RESULTS: IMT was significantly higher in HTN than in C (0.6 +/- 0.1 vs 0.4 +/- 0.1 mm, p < 0.001) as well as LVMI (119.5 +/- 39.9 vs 106.8+/-18.7 g/m2, p = 0.04) and serum TIMP-1 (in HNT 691.7 +/- 124.6 ng/ml; in C 577.5+/-70.8 ng/ml, p < 0.001). Other parameters did not differ between these groups. The sum of PICP and ICTP was higher in HTN (165.0 +/- 46.9 microg/l), than in C (147.1 +/- 26.0 microg/l, p = 0.03). TIMP-1 correlated with IMT (r = 0.33, p = 0.02) in hypertensives. CONCLUSIONS: We suggest that the collagenase-anticollagenase system is abnormal in essential hypertension and contributes to cardiovascular remodeling. Increased IMT may be related to the accumulation of extracellular proteins due to altered metabolism of collagen.
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Szmigielski et al. (2006) conducted an observational in Essential hypertension (n=64). Essential hypertension vs. Controls was evaluated on Intima media thickness (IMT) (p=<0.001). Newly diagnosed, untreated essential hypertension in males was associated with significantly higher intima media thickness (0.6 vs 0.4 mm, p<0.001) and serum TIMP-1 levels compared to controls.
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