January 1, 1999Transplantation

Intercellular Adhesion Molecule-1 Expression in Endothelial Cells Is Activated by Cytomegalovirus Immediate Early Proteins1

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Population

Human umbilical vein endothelial cells (HUVECs)

Design

Preclinical

Authors

LBLinda J. BurnsVersiti Blood Center of Wisconsin JPJoan C. PooleyUniversity of Minnesota DWDaniel J. WalshDartmouth College

Discussion

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Implication

Supports direct viral role in allograft vasculopathy; leaves open whether IE protein inhibition reduces rejection in humans.

Structured PICO

Population

Human umbilical vein endothelial cells (HUVECs)

Intervention

Infection with human cytomegalovirus (HCMV) and transient transfection with plasmid constructs containing ICAM-1 and HCMV immediate early (IE) gene sequences

Outcome

ICAM-1 mRNA levels and ICAM-1 promoter expressionsurrogate

HCMV directly upregulates ICAM-1 expression in endothelial cells via immediate early proteins, suggesting a molecular mechanism for HCMV-associated allograft vasculopathy.

Cite This Study

Burns et al. (1999) studied this question.

synapsesocial.com/papers/6a884eb9c16cbaca05f4d1fb https://doi.org/10.1097/00007890-199901150-00023

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Intercellular Adhesion Molecule-1 Expression in Endothelial Cells Is Activated by Cytomegalovirus Immediate Early Proteins1

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Intercellular Adhesion Molecule-1 Expression in Endothelial Cells Is Activated by Cytomegalovirus Immediate Early Proteins1

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider