April 1, 1999Journal of Biological ChemistryOpen Access

Cloning of a New Mouse Two-P Domain Channel Subunit and a Human Homologue with a Unique Pore Structure

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Population

Mouse KCNK6 and human KCNK7 genes/proteins expressed in COS-7 cells

Design

Preclinical

Authors

MSMiguel SalinasCentre National de la Recherche Scientifique RRRoberto V. ReyesUniversidad de Santiago de Chile FLFlorian LesageElectrophysiology

Discussion

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Implication

KCNK6/7 likely require heteromerization for activity; leaves open partner identification and native roles in mammalian tissues.

Structured PICO

Population

Mouse KCNK6 and human KCNK7 genes/proteins expressed in COS-7 cells

Intervention

Cloning, expression, deletions, mutations, and chimera constructions

Outcome

Channel activity and cellular localization

The study identifies novel two-P domain channel subunits (mouse KCNK6 and human KCNK7) that require an unknown partner for functional plasma membrane expression.

Cite This Study

Salinas et al. (1999) studied this question.

synapsesocial.com/papers/6a884ec4ce59b4d55bcf12c6 https://doi.org/10.1074/jbc.274.17.11751

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Cloning of a New Mouse Two-P Domain Channel Subunit and a Human Homologue with a Unique Pore Structure

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Cloning of a New Mouse Two-P Domain Channel Subunit and a Human Homologue with a Unique Pore Structure

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider