Key result
Left heart mechanical valve replacement in West African children achieved a 15-year actuarial survival of 94.0% with a low prosthetic valve thrombosis rate of 0.56% per patient-year.
Population
114 children undergoing left heart mechanical valve replacement, mean age 13.3 ± 3.1 years, 57.9% female…
Design
Cohort
Follow-up
median 9.1 years
Authors
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Supports feasibility in resource-limited settings; extends data to West African children but remains hypothesis-generating.
Cohort (n=114)
No
Mechanical valve replacement in West African children with advanced rheumatic heart disease provides excellent long-term survival and acceptably low valve-related complications, demonstrating feasibility despite the socioeconomic challenges of lifelong anticoagulation.
Edwin et al. (2011) conducted a cohort in Left heart valve disease (predominantly rheumatic heart disease) (n=114). Left heart mechanical valve replacement was evaluated on 15-year actuarial survival. Left heart mechanical valve replacement in West African children achieved a 15-year actuarial survival of 94.0% with a low prosthetic valve thrombosis rate of 0.56% per patient-year.
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