Population
Tissue kallikreins purified from rat submandibular gland (SMG) and human urine
Design
Preclinical
Authors
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May indicate tissue kallikrein bypasses ACE for Ang II production; leaves open relevance to ACE inhibitor escape in humans.
Tissue kallikrein can convert angiotensin I to angiotensin II independently of ACE, suggesting an alternative pathway for angiotensin II formation during ACE inhibitor therapy.
Ideishi et al. (2008) studied this question.
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