Why the study?
Does sodium restriction alter nitric oxide synthesis and renin-angiotensin system activity in relation to sodium sensitivity in normotensive patients with IgA nephropathy?
Population
39 Japanese inpatients with IgA nephropathy without hypertension, aged 20 to 59 years, 11 men and 28 women.
Comparison
Low-sodium diet for 1 week and ordinary sodium… vs Within-subject comparison between low-sodium and…
Design
RCT, Random order of diets
Follow-up
2 weeks (1 week per diet)
Authors
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Blunted RAAS response during sodium restriction marks sodium sensitivity in IgA nephropathy; extends mechanisms to normotensive patients.
Does sodium restriction alter nitric oxide synthesis and renin-angiotensin system activity in relation to sodium sensitivity in normotensive patients with IgA nephropathy?
In normotensive patients with IgA nephropathy, altered sodium sensitivity of blood pressure is associated with impaired nitric oxide synthesis and a blunted response of the renin-angiotensin-aldosterone system.
Konishi et al. (2004) studied this question.
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