Why the study?
Does high dietary sodium intake alter ANF and renal function differently in offspring of hypertensive versus normotensive parents?
Population
42 subjects, comprising 22 offspring of hypertensive parents and 20 offspring of normotensive parents
Comparison
High dietary sodium intake for 4 days vs Low dietary sodium intake (50 mmol/day) for 4 days
Design
RCT, The diets were allocated randomly
Follow-up
4 days per diet
Authors
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High sodium intake elicits similar ANF and renal responses regardless of parental hypertension history; does not support ANF dysregulation hypothesis in hypertension-prone offspring.
Does high dietary sodium intake alter ANF and renal function differently in offspring of hypertensive versus normotensive parents?
The study does not support the hypothesis of a dysregulation of atrial natriuretic factor in hypertension-prone humans, as renal and neuroendocrine responses to sodium loading were similar regardless of parental hypertension history.
Niels Eske Bruun (2000) studied this question.
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