What question did this study set out to answer?

Determine whether isolated femoral resistance vessels or tail arteries better replicate the morphological and pharmacological characteristics of hindquarter vasculature in spontaneously hypertensive rats.

November 1, 1982Acta Physiologica Scandinavica

Are isolated femoral resistance vessels or tail arteries good models for the hindquarter vasculature of spontaneously hypertensive rats?

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Population

Spontaneously hypertensive rats (SHRs) and control Wistar-Kyoto rats (WKYs)

Comparison

In vitro morphological and pharmacological… vs Vessels from control Wistar-Kyoto rats (WKYs)

Design

Preclinical

Authors

MMMichael J. MulvanyVascular / Pulmonary Vascular HNHolger NilssonUniversity of Gothenburg NNNiels C. Berg NyborgNovo Nordisk (Denmark)

Discussion

Member takes

Implication

Femoral resistance vessels better model SHR hindquarter vasculature than tail arteries; extends vessel-specific phenotyping criteria in preclinical hypertension studies.

Key Points

Determine whether isolated femoral resistance vessels or tail arteries better replicate the morphological and pharmacological characteristics of hindquarter vasculature in spontaneously hypertensive rats.
Compared in vitro morphological and pharmacological properties of isolated femoral resistance vessels (internal diameter ~200 µm) and tail arteries (internal diameter ~600 µm).
Evaluated isolated vessels from spontaneously hypertensive rats (SHRs) alongside normotensive Wistar-Kyoto rat (WKY) controls under relaxed and noradrenaline-activated states.
Relaxed SHR femoral resistance vessels exhibited reduced internal circumference at given wall tensions, whereas SHR tail arteries maintained normal internal circumference.
Under 10 µM noradrenaline stimulation, SHR femoral resistance vessels showed increased calcium sensitivity and normal noradrenaline sensitivity, whereas SHR tail arteries exhibited normal calcium sensitivity and reduced noradrenaline sensitivity.
Both SHR vessel preparations exhibited maximum contractile responses adequate to contract against elevated transmural pressure.

Structured PICO

Population

Spontaneously hypertensive rats (SHRs) and control Wistar-Kyoto rats (WKYs)

Intervention

In vitro morphological and pharmacological evaluation of femoral resistance vessels (i.d. ca 200 microns) and tail arteries (i.d. ca 600 microns)

Comparator

Vessels from control Wistar-Kyoto rats (WKYs)

Outcome

Morphological and pharmacological properties (internal circumference, calcium sensitivity, maximum response, noradrenaline sensitivity)surrogate

Femoral resistance vessels are a better model for the hindquarter vasculature of spontaneously hypertensive rats than tail arteries.

Cite This Study

Mulvany et al. (1982) studied this question.

synapsesocial.com/papers/6a88ece09f05dd9930a2a8c0 https://doi.org/10.1111/j.1748-1716.1982.tb07141.x

Topics

Hypertension management

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Implication

Femoral resistance vessels better model SHR hindquarter vasculature than tail arteries; extends vessel-specific phenotyping criteria in preclinical hypertension studies.

Are isolated femoral resistance vessels or tail arteries good models for the hindquarter vasculature of spontaneously hypertensive rats?

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Are isolated femoral resistance vessels or tail arteries good models for the hindquarter vasculature of spontaneously hypertensive rats?

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider