Why the study?
Does a 10-minute venous occlusion affect PAI activity and fibrinolytic response in patients with confirmed deep vein thrombosis?
Population
83 patients with confirmed deep vein thrombosis, studied at least 3 months after the last acute episode
Comparison
10-minute venous occlusion (venous stasis) vs Baseline (before venous occlusion)
Design
Cohort
Authors
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May stratify DVT patients by post-occlusion fibrinolytic response; leaves open prognostic or therapeutic utility.
Does a 10-minute venous occlusion affect PAI activity and fibrinolytic response in patients with confirmed deep vein thrombosis?
Residual PAI activity after venous stasis can classify DVT patients into good or bad responders, identifying hypofibrinolysis in 54% of patients due to insufficient t-PA release or increased basal PAI activity.
Nguyen et al. (1988) studied this question.
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