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January 1, 1974Cold Spring Harbor Symposia on Quantitative Biology

The Detection and Quantitation of SV40 Nucleic Acid Sequences Using Single-stranded SV40 DNA Probes

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Population

Monkey cells productively infected or transformed by SV40 or polyoma virus

Design

Preclinical

Authors

GKGeorge KhouryNational Institutes of HealthPHPeter M. HowleyRutgers, The State University of New JerseyMBMatthew BrownGlobal Policy Institute

Discussion

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Implication

Differential SV40 transcription informs viral models; leaves open human oncogenesis relevance.

Structured PICO

P
Population
Monkey cells productively infected or transformed by SV40 or polyoma virus
I
Intervention
Single-stranded SV40 DNA probes and hybridization techniques
O
Outcome
Detection and quantitation of SV40 nucleic acid sequences (virus-specific RNA)surrogate

The study demonstrates the use of single-stranded SV40 DNA probes to quantify virus-specific RNA transcription phases in infected and transformed cells.

Cite This Study

Khoury et al. (1974) studied this question.

synapsesocial.com/papers/6a88fa1fe88fc9ac761a2425https://doi.org/10.1101/sqb.1974.039.01.020
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Detection of virus‐specific DNA sequences by quantitative in situ hybridization during infection with SV401975 · 6 citations
  2. 2Hybridization in Situ of SV40 Plaques: Detection of Recombinant Sv40 Virus Carrying Specific Sequences of Nonviral DNA1977 · 109 citations
  3. 3Isolation of viral specific RNA from SV40 infected cells by viral DNA chemically linked to a cellulose matrix1976 · 9 citations
  4. 4Regulation of Simian Virus 40 Transcription: Sensitive Analysis of the RNA Species Present Early in Infections by Virus or Viral DNA1979 · 621 citations
  5. 5Regulation of transcription of the SV40 DNA in productively infected and in transformed cells.1968 · 143 citations