What does this research mean for the field?

Targeting glutamine metabolism, including its key enzymes and transporters, presents a significant therapeutic strategy for inhibiting tumor metastasis by disrupting cancer cells' ability to resist oxidative stress and promote immune escape. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To review the metabolic rewiring of glutamine in cancer cells and elucidate its functional roles and therapeutic potential in tumor metastasis.

October 1, 2023HeliyonOpen Access

Glutamine metabolism in tumor metastasis: Genes, mechanisms and the therapeutic targets

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Authors

XZXugang Zhong ZHZeju He YLYin Li

Discussion

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Overview

Narrative review demonstrates how glutamine metabolism drives tumor metastasis and immune escape in cancer cells, highlighting novel targets for antimetastatic therapies.

Key Points

To review the metabolic rewiring of glutamine in cancer cells and elucidate its functional roles and therapeutic potential in tumor metastasis.
Synthesized molecular evidence on cancer metabolic shifting from aerobic glycolysis to amino acid and lipid metabolism during metastatic progression.
Evaluated the roles of specific glutamine transporters and metabolic enzymes in primary tumor detachment, apoptosis evasion, oxidative stress defense, and distant colonization.
Glutamine metabolism acts as a key driver across multiple metastatic stages, facilitating cell shedding, anoikis resistance, and colonization of target organs.
Enhanced glutamine utilization aids metastatic tumor cells in mitigating oxidative stress and evading host immune surveillance.
Pharmacological targeting of key enzymes and transporters in the glutamine metabolic pathway represents a promising strategy to suppress metastatic spread.

Cite This Study

Zhong et al. (2023) studied this question.

synapsesocial.com/papers/6a8901c19f05dd9930a2ae6d https://doi.org/10.1016/j.heliyon.2023.e20656

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October 1, 2023HeliyonOpen Access

Glutamine metabolism in tumor metastasis: Genes, mechanisms and the therapeutic targets

View Full Paper

Ask AI

Bookmark

Authors

XZXugang Zhong ZHZeju He YLYin Li

Discussion

Member takes

Overview

Narrative review demonstrates how glutamine metabolism drives tumor metastasis and immune escape in cancer cells, highlighting novel targets for antimetastatic therapies.

Key Points

To review the metabolic rewiring of glutamine in cancer cells and elucidate its functional roles and therapeutic potential in tumor metastasis.
Synthesized molecular evidence on cancer metabolic shifting from aerobic glycolysis to amino acid and lipid metabolism during metastatic progression.
Evaluated the roles of specific glutamine transporters and metabolic enzymes in primary tumor detachment, apoptosis evasion, oxidative stress defense, and distant colonization.
Glutamine metabolism acts as a key driver across multiple metastatic stages, facilitating cell shedding, anoikis resistance, and colonization of target organs.
Enhanced glutamine utilization aids metastatic tumor cells in mitigating oxidative stress and evading host immune surveillance.
Pharmacological targeting of key enzymes and transporters in the glutamine metabolic pathway represents a promising strategy to suppress metastatic spread.

Cite This Study

Zhong et al. (2023) studied this question.

synapsesocial.com/papers/6a8901c19f05dd9930a2ae6d https://doi.org/10.1016/j.heliyon.2023.e20656

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